Diaminopyrimidine oxide
An ingredient treats hair loss by softening collagen to prevent follicle hardening and fibrosis, and by inhibiting 5α-reductase to reduce the formation of the hair loss-causing hormone DHT; can be used in anti-hair loss care products such as hair water, hair milk, conditioner, scalp lotion, and hair spray.
Overview
Diaminopyrimidine Oxide softens collagen, aiding hair care products to treat hair loss from premature root damage. It inhibits lysyl hydroxylase to prevent fibrosis: this enzyme hydroxylates collagen lysines, causing accumulation, hardening, and follicle contraction, delaying growth and leading to follicle death. It also suppresses 5α-reductase, reducing testosterone conversion to DHT. Suitable for hair oils, conditioners, tonics, shampoos, gels, and seasonal hair loss treatments. Recommended dosage: 0.5%-2% for prevention; 2%-5% for treatment.
Synonyms: Aminexil; Kopexil; 2,4-Pyrimidinediamine 3-oxide; 2,4-Pyrimidinediamine, 3-oxide (9CI);pyrimidine-2,4-diamine 3-oxide;2,4-Diaminopyrimidine 3-N-oxide; 2,4-DIAMINO PYRIMIDINE-3-OXIDE; 2,4-DIAMINO PYRIMIDINE-3-OXIDE ISO 9001：2015 REACH
EINECS: 616-121-2
Mol File: 74638-76-9.mol
Physicochemical Properties
Boiling point: 475.5±37.0 °C
Density: 1.69±0.1 g/cm3
Pka: 5.04±0.47
Storage condition: Sealed storage in a cool and dry place, avoid light and heat.
MSDS Information
Experimental Data
Pharmacodynamics
Mechanism Of Action
The mechanism of action of Diaminopyrimidine Oxide is to repair the weakened hair follicle cells of the scalp by supplying nutrients and oxygen, prolong the hair growth cycle, and act on the deep structure of the hair root to stimulate the regeneration of hair follicles, open potassium ion channels, and promote the proliferation of hair papilla cells, so as to strengthen and nourish hair and accelerate the growth of new hair. As a new type of anti-hair loss raw material, Diaminopyrimidine Oxide has high water solubility, is alcohol-free, and has a mild formula.
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