Technology Platforms
Advanced Reaction Tech
In pharmaceutical compound and advanced intermediate synthesis, core challenges include precise chiral control, intrinsically safe processes, and green continuous production. We integrate cutting-edge technologies such as Flow Chemistry, Biocatalysis, Chiral Synthesis, Low-Temperature & High-Pressure Reactions, Photochemistry, Crystallization & Powder Engineering, Preparation & Purification, and High-Throughput Screening, coupled with full lifecycle analytical quality control and method development. We deliver efficient, low-carbon, and scalable solutions for API and intermediate manufacturing worldwide.
Flow Chemistry
Flow chemistry is a continuous process technology based on microreactors, enabling precise control over reaction conditions through millisecond-level mass/heat transfer and modular system integration. It is particularly suited for synthesizing highly active APIs and intermediates, effectively addressing challenges such as thermal/oxygen sensitivity, stereoselectivity, and scale-up issues while enhancing atom economy, process continuity, and avoiding common industry problems like degradation, metal contamination, and structural non-uniformity.
Biocatalysis
Biocatalysis leverages expert expertise and advanced facilities to replace chiral metal catalysts with enzyme-based solutions, offering end-to-end services from enzyme design and process development to customized production. Specializing in highly selective reductions (e.g., aldehydes/ketones) without over-reduction byproducts, our technology ensures process stability, cost efficiency, and scalability in support of sustainable chemistry.
Chiral Synthesis
Chiral Synthesis Technology focuses on addressing critical issues such as substantial loss of API bioactivity caused by stereochemical deviations. By integrating core technologies including stereodirected catalysis, enzymatic biotransformation, and microfluidic process control, we enable efficient and precise construction of complex chiral molecules, particularly for the synthesis of high-purity chiral intermediates and APIs.
Low-Temperature Synthesis
Low-temperature synthesis technology focuses on addressing the degradation and inactivation issues of thermosensitive APIs and intermediates during synthesis. Leveraging dual platforms operating at -90°C (batch) and -110°C (continuous flow), along with industrial cryogenic reactors, energy-efficient continuous flow processes, and molecular-level temperature control, we achieve precise, stable, and scalable production of highly sensitive molecules.
High-Pressure Chemistry
Our high-pressure chemistry platform specializes in industrial-scale hydrogenation for the synthesis of APIs and intermediates. Integrating 4-9 MPa high-pressure systems (300-3,000L Hastelloy® reactors) with intelligent constant-pressure control (±0.1 MPa dynamic regulation), and enabled by real-time hydrogen absorption kinetics monitoring and full data-driven operation, we achieve highly selective olefin reduction and precise chiral center construction enhancing both reaction efficiency and stereochemical control.
Photochemistry
The photochemistry technology platform utilizes continuous-flow photoreactors with customized full-spectrum LED light sources and millimeter-scale microfluidic channels to achieve millisecond mixing and highly efficient photon utilization. It significantly enhances reaction selectivity and energy efficiency while avoiding common side reactions and multi-step processes.
Crystallization & Powder Engineering
Leveraging advanced instrumentation, our platform offers integrated development services for small-molecule drugs, spanning from solid-form screening to industrial-scale manufacturing. We specialize in the systematic development of polymorphs, salts, and co-crystals, and provide comprehensive support in crystallization process development and optimization, powder processing, and performance evaluation ensuring enhanced stability, processability, and bioavailability of solid forms to accelerate innovative drug development.
Preparation & Purification
Our platform specializes in providing efficient and precise separation and purification solutions from milligram to kilogram scale for innovative APIs and high-value intermediates. Equipped with multiple advanced chromatographic technologies (including normal/reverse-phase HPLC, SFC supercritical fluid chromatography, and CPC centrifugal partition chromatography), we support the isolation, purification, and preparation of APIs, critical intermediates, impurities, peptides, and fermentation products.