Arimoclomol citrate

Arimoclomol citrate•Central nervous system and pain

CAS: 368860-21-3

MF: C20H28ClN3O10

MW: 505.91

适应症

Niemann-Pick Disease, Type C; Amyotrophic Lateral Sclerosis; Myositis, Inclusion Body; Gaucher's Disease Type III; Gaucher's Disease Type I

作用靶点

用途

A heat shock protein (HSP) inducer,It is potentially used in the treatment of neurodegenerative diseases and lysosomal storage diseases , aiming to alleviate disease progression and improve symptoms by enhancing cellular protein homeostasis and stress resistance.

规格标准

＞99%

描述

概况

Arimoclomol citrate is a potent oral small-molecule heat shock protein (HSP) inducer, with the functions of activating the heat shock response and enhancing cellular stress tolerance. Arimoclomol citrate can be used in the research of neurodegenerative diseases (such as amyotrophic lateral sclerosis and Huntington's disease), rare lipid metabolism diseases (such as Niemann-Pick disease type C) and cell stress-related diseases.

Synonyms: Arimoclomol citrate; BRX-220 citrate; (2R-)Arimoclomol citrate; OR-01; OR-04; BRX-220; BRX-345; Orphazyme OR-01; MY-PLY-FAH; Miplyffa; Arimoclomolum; Arimoclomol

Mol File: 368860-21-3.mol

物化性质

Storage temp: 2-8°C

Form: Solid

Color: White to Off-white

MSDS信息

实验数据

Cell Experiment

Solubility in DMSO : 35 mg/mL (69.18 mM; ultrasonic co-solubilization; Hygroscopic DMSO has a significant effect on the solubility of the product, use freshly opened DMSO)

Preparing Stock Solutions：

Please choose the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; Once prepared into a solution, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and duration of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture).Use within 6 months when stored at -80°C, and within 1 month when stored at -20°C.

Pharmacodynamics

Mechanism Of Action

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