GSK-2881078

GSK-2881078

GSK-2881078Musculoskeletal diseases
CAS: 1539314-06-1
MF: C14H13F3N2O2S
MW: 330.33
适应症
Cachexia
作用靶点
AR
用途

An experimental SARM for muscle failure has entered Phase II clinical trials.

规格标准
>99%
描述

概况

GSK-2881078 is an oral nonsteroidal SARM known for tissue-selective agonism, promoting lean mass gains and muscle strength with enhanced sensitivity in women, while minimizing prostate effects. It combats muscle weakness and cachexia, showing dose-dependent anabolic benefits in clinical trials with good tolerability. Widely researched for sarcopenia, COPD, and age-related decline.

Synonyms: GSK-2881078A; GSK2881078; SARMGS2881078; CS-2336; GSK-2881078(Freebase); 1H-Indole-5-carbonitrile,1-[(1R)-1-methyl-2-(methylsulfonyl)ethyl]-4-(trifluoromethChemicalbookyl)-;1-[(2R)-1-(Methylsulfonyl)-2-propanyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile; 1-(1-Methylsulfonylpropan-2-yl)-4-(trifluoromethyl)indole-5-carbonitrile

EINECS: 1539314-060-1

Product Categories: Inhibitors; scientific research original drug series (SARM series); SARM series

Mol File: 1539314-06-1.mol

物化性质

Boiling point: 521.6±50.0°C(Predicted)

Density: 1.36±0.1g/cm3(Predicted)

Storage temp.: Store at -20°C

Solubility: ≤20mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide

Form: crystalline solid

Color: White to off-white

MSDS信息

实验数据

1.Cell Experiment

Solubility in DMSO: ≥ 33 mg/mL (99.90 mM; Hygroscopic DMSO significantly affects the solubility of the product, please use freshly opened DMSO)

* "≥" means soluble, but saturation unknown.

Preparing Stock Solutions:

image

Please choose a suitable solvent to prepare the stock solution based on the product's solubility in different solvents. Once the solution is prepared, aliquot and store it to avoid product degradation caused by repeated freeze-thaw cycles.

Storage conditions and shelf life of the stock solution: -80°C for 2 years; -20°C for 1 year. When stored at -80°C, use within 2 years; when stored at -20°C, use within 1 year.

Pharmacodynamics

Mechanism Of Action