GSK-2881078
An experimental SARM for muscle failure has entered Phase II clinical trials.
Overview
GSK-2881078 is an oral nonsteroidal SARM known for tissue-selective agonism, promoting lean mass gains and muscle strength with enhanced sensitivity in women, while minimizing prostate effects. It combats muscle weakness and cachexia, showing dose-dependent anabolic benefits in clinical trials with good tolerability. Widely researched for sarcopenia, COPD, and age-related decline.
Synonyms: GSK-2881078A; GSK2881078; SARMGS2881078; CS-2336; GSK-2881078(Freebase); 1H-Indole-5-carbonitrile,1-[(1R)-1-methyl-2-(methylsulfonyl)ethyl]-4-(trifluoromethChemicalbookyl)-;1-[(2R)-1-(Methylsulfonyl)-2-propanyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile; 1-(1-Methylsulfonylpropan-2-yl)-4-(trifluoromethyl)indole-5-carbonitrile
EINECS: 1539314-060-1
Product Categories: Inhibitors; scientific research original drug series (SARM series); SARM series
Mol File: 1539314-06-1.mol
Physicochemical Properties
Boiling point: 521.6±50.0°C(Predicted)
Density: 1.36±0.1g/cm3(Predicted)
Storage temp.: Store at -20°C
Solubility: ≤20mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
Form: crystalline solid
Color: White to off-white
MSDS Information
Experimental Data
1.Cell Experiment
Solubility in DMSO: ≥ 33 mg/mL (99.90 mM; Hygroscopic DMSO significantly affects the solubility of the product, please use freshly opened DMSO)
* "≥" means soluble, but saturation unknown.
Preparing Stock Solutions:
Please choose a suitable solvent to prepare the stock solution based on the product's solubility in different solvents. Once the solution is prepared, aliquot and store it to avoid product degradation caused by repeated freeze-thaw cycles.
Storage conditions and shelf life of the stock solution: -80°C for 2 years; -20°C for 1 year. When stored at -80°C, use within 2 years; when stored at -20°C, use within 1 year.
Pharmacodynamics
Mechanism Of Action
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