AC Series SARMs: New Advances in Non-Steroidal, Muscle-Selective Research Tools
In the field of anabolic research, non-steroidal Selective Androgen Receptor Modulators (SARMs) have attracted significant attention due to their potential tissue selectivity. The AC series SARMs, such as AC-262536 and AC-262,356, represent a new generation of research compounds designed to explore the mechanisms of muscle growth and strength enhancement while minimizing the side effects associated with traditional androgen therapies. PHMO supplies high-purity AC series raw materials, providing reliable support for your preclinical research and drug development projects.
With the growing demand for precise anabolic interventions, non-steroidal SARMs offer a more selective tool for studying muscle regeneration, performance enhancement, and related metabolic diseases. AC series compounds, characterized by their well-defined structural features and preclinical data, serve as important research vehicles for exploring the function of androgen receptors in muscle tissue. These products are strictly limited to laboratory research use only.
1. Function & Core Research Applications
l AC-262536 (CAS 870888-46-3)
As a potent, orally bioavailable non-steroidal SARM, it exhibits significant selective agonist activity for muscle tissue in preclinical models. Research primarily focuses on exploring its potential to promote lean body mass growth, enhance muscle strength, and counteract muscle atrophy (e.g., age-related or disease-associated). Its structural optimization aims to achieve stronger myoanabolic effects with lower risk of off-target tissue activation.
l AC-262,356 (CAS 871032-12-1)
This compound is a structural analog of AC-262536, sharing the core pharmacophore, and is designed for further study of structure-activity relationships and its selectivity toward androgen receptor subtypes or signaling pathways. It is used for in-depth research on muscle growth mechanisms, exploration of anabolic pathways, and as a tool in comparative studies to evaluate the impact of different structural modifications on potency and selectivity.
Note: All AC series products supplied by PHMO are for in vitro or preclinical research use only. Strictly not for human use.
2. Differentiating Features & Advantages
Compared to traditional androgens, the AC series demonstrates superior tissue selectivity, aiming to maximize anabolic effects on muscle and bone while minimizing side effects such as prostate hyperplasia and hepatotoxicity. This tissue-selective profile makes them ideal tool compounds for studying "pure" muscle anabolic mechanisms and developing potential new therapies for muscle atrophy. AC-262536, as a partial agonist, fully activates muscle tissue while exerting weaker effects on the prostate, offering a unique androgen-to-anabolic ratio (approximately 66%:27% relative to testosterone). AC-262,356 extends this selectivity and is suitable for exploring models where prostate-related diseases coexist with muscle loss. Compared to other SARMs (e.g., the LGD series, which focuses more on bone), the AC series emphasizes prostate protection. Both compounds are orally active, facilitating experimental design, and their pharmacokinetics show tissue specificity independent of plasma concentration.
3. Target Audience & Market Validation
This product series primarily serves academic institutions, pharmaceutical R&D departments, and Contract Research Organizations (CROs) engaged in muscle physiology, sports science, geriatrics (sarcopenia), and metabolic disease research. AC-262536 is supported by preclinical data and holds reference value in sarcopenia drug development. AC-262,356, due to its similar mechanism, is of interest in studies related to tissue-selective pharmacology and prostate health. The global SARMs research market continues to expand, particularly in the fields of precision medicine and translational research. With their weak androgenic effects, the AC series has become a tool compound in numerous R&D projects. It is reiterated that all products are for scientific research use only.
From mechanistic studies to translational exploration, reliable research materials are the foundation of scientific discovery. PHMO provides a strict Certificate of Analysis (COA) for every batch of AC series products, ensuring that your research data are accurate and reproducible. Please contact us for product details and quotations, or leave a comment below to share your research direction and needs. PHMO—Your Trusted Partner for Research Materials!