4-chlorobenzo[b]thiophene

4-Chlorobenzo[b]thiophene serves as a crucial synthetic intermediate in the preparation of brexpiprazole and related central nervous system (CNS) therapeutics. This versatile building block undergoes nucleophilic aromatic substitution reactions with piperazine derivatives to construct the core benzo[b]thiophene-piperazine scaffold essential for 5-HT1A receptor antagonism. Its reactivity enables the synthesis of 1-aryloxy-3-piperidinylpropan-2-ol derivatives that demonstrate dual pharmacological activity, making it particularly valuable in developing novel antipsychotic agents targeting serotonin receptors for the treatment of mental disorders.

Synonyms: 4-chloro- Benzo[b]thiophene;Benzo[b]thiophene, 4-chloro-;4-Chlorobenzothiophene;4-chloro-1-benzothiophene;4-chloro- Benzo[b]thiophene ISO 9001：2015 REACH

Mol File: 66490-33-3.mol