1-(1-Benzothiophen-4-yl)piperazine hydrochloride
Used as a pharmaceutical intermediate; used to prepare piperazine-substituted benzothiophenes for the treatment of central nervous system disorders.
Overview
1-(Benzo[b]thiophen-4-yl)piperazine hydrochloride serves as a key synthetic intermediate for Brexpiprazole and other CNS-targeting therapeutics. This piperazine-substituted benzothiophene derivative participates in nucleophilic substitution reactions to construct the core molecular framework of atypical antipsychotics, enabling effective treatment of mental disorders.
Synonyms: 1-(1-Benzothiophen-4-yl)piperazine hydrochloride;Piperazine, 1-benzo[b]thien-4-yl-, hydrochloride;Brexpiprazole Intermediate 2;1-benzo[b]thien-4-yl-;1-benzo[b]thien-4-yl-, hydrochloride;1-Benzo[b]thien-4-ylpiperazine Monohydrochloride;1-(1-benzothiophen-4-yl)piperazine hydrochloride;7-(4-chlorobutoxy)-1-(4-chlorobutyl)quinolin-2(1H)-one
EINECS: 812-454-4
Mol File: 913614-18-3.mol
Physicochemical Properties
Melting point: >250°C
Storage temp: Keep in dark place,Sealed in dry,Room Temperature
Solubility: DMSO (Slightly, Heated), Methanol (Very Slightly)
Form: Solid
Color: White