7-(4-chlorobutoxy)quinolin-2(1H)-one
Used as a pharmaceutical intermediate; serves as an impurity of Brexipiprazole (B677385), a drug candidate for CNS disorders.
Overview
7-(4-Chlorobutoxy)quinolin-2(1H)-one is a key intermediate in synthesizing Brexpiprazole, an antipsychotic drug for CNS disorders. This compound is formed through O-alkylation reactions and serves as a crucial precursor in constructing the quinolinone core structure of brexpiprazole, while also being monitored as a process-related impurity during manufacturing.
Synonyms: 7-(4-Chlorobutoxy)-1H-quinolin-2-one;2(1H)-Quinolinone,7-(4-chlorobutoxy)-;7-(4-Chlorobutoxy)-1H-quinolin-2-one;7-(4-chlorobutoxy)-2(1H)-Quinolinone;Ipiprazole Impurity 7;2-(2-carboxy-4-nitrophenyl)-5-nitrobenzoic acid;7-(4-chlorobutoxy)-4a,8a-dihydroquinolin-2(1H)-one;Aripiprazole impurities1774
Mol File: 913613-82-8.mol
Physicochemical Properties
Melting point: 126 - 128°C
Boiling point: 460.8±45.0°C
Storage temp: Inert atmosphere,Room Temperature
Solubility:Chloroform (Slightly, Sonicated), DMSO (Slightly, Sonicated)
Form: Solid
Color: Pale Yellow to Pale Beige