7-hydroxyquinolin-2(1H)-one
Used as a pharmaceutical intermediate; related to the quinolinone impurity of Aripiprazole.
Overview
7-Hydroxyquinolin-2(1H)-one is a key carbostyril derivative used as a pharmaceutical intermediate. It serves as a crucial building block for synthesizing atypical antipsychotics like Brexpiprazole through nucleophilic substitution and condensation reactions, and also exists as a process-related impurity in aripiprazole manufacturing.
Synonyms: 7-Hydroxyquinolinone;2,7-DIHYDROXYQUINOLINE;7-HYDROXYQUINOLINE-(1H)-2-ONE;3,4-Dihydro-7-hydroxyquinoline-2(1H)-one;3,4-DIHYDRO-7-HYDROXY-2(1H)-QUINOLINE;7-Hydroxycarbostyril;7-HYDROXY-2-QUINOLINONE;7-HYDROXY-1H-QUINOLIN-2-ONE
EINECS: 812-453-9
Product Categories: Aromatics Compounds;Quinoline;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles
Mol File: 70500-72-0.mol
Physicochemical Properties
Melting point: 187-192°C
Boiling point: 426.8±45.0 °C
Storage temp: Inert atmosphere,Room Temperature
Solubility:DMSO (Slightly), Methanol (Slightly, Sonicated)
Water Solubility: Insoluble
Form: Solid
Color: Off-White to Pale Yellow