3-chloro-5-(3-chlorophenyl)picolinonitrile

3-Chloro-5-(3-chlorophenyl)picolinonitrile serves as a key intermediate in synthesizing Vadadustat, an oral HIF-PH inhibitor for treating anemia. This compound enables construction of the core pyridine scaffold through sequential chlorination and cyanation reactions, followed by Suzuki cross-coupling to establish the essential biphenyl structure of the drug molecule.

Synonyms: 5-(3-chlorophenyl)-3-chloro-2-cyanopyridin;2-Pyridinecarbonitrile, 3-chloro-5-(3-chlorophenyl)-;3-chloro-5-(3-chlorophenyl)pyridine-2-carbonitrile;3-chloro-5-(3-chlorophenyl)picolinonitrile

Mol File: 1415226-38-8.mol