(3-chlorophenyl)boronic acid
Used as a pharmaceutical intermediate; used in key organic reactions including Suzuki-Miyaura cross-coupling and 1,4-conjugate additions for the synthesis of biarylketones, phthalides, and enzyme inhibitors.
Overview
(3-Chlorophenyl)boronic acid is a versatile synthetic intermediate extensively utilized in pharmaceutical chemistry. It serves as a key building block in Suzuki-Miyaura cross-coupling reactions for constructing biarylketones and other complex architectures. Additionally, it participates in 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides, and finds application in synthesizing PDE4 inhibitors through various coupling methodologies.
Synonyms: B-(3-chlorophenyl)-boronic acid;3-Chlorobenzeneboronic acid 98%;3-Chlorophenylboronic;3-Chlorophenylboornic acid;RARECHEM AH PB 0179;3-CHLOROPHENYLBORNIC ACID;3-CHLOROPHENYLBORONIC ACID;3-CHLOROBENZENEBORONIC ACID
EINECS: 628-786-6
Product Categories: Boronate Ester;Potassium Trifluoroborate;Boronic acids;Aryl;Halogenated;Organoborons;blocks;BoronicAcids;Boronic Acid series;Substituted Boronic Acids;Boronic Acid;B (Classes of Boron Compounds);Boronic Acids;Boronic Acids and Derivatives
Mol File: 63503-60-6.mol
Physicochemical Properties
Melting point: 185-189°C
Boiling point: 311.4±44.0 °C
Storage temp: Inert atmosphere,Room Temperature
Solubility: Soluble in methanol
Water Solubility: Slightly soluble in water. soluble in ether, tetrahydrofuran,, dimethyl sulfoxide, dimethyl formamide, methanol.
Form: Crystalline powder or needles
Color: White to light yellow-green