3,5-dichloropicolinonitrile
Used as a pharmaceutical intermediate; used in the industrial synthesis of nicotinic acid and nicotinamide.
Overview
3,5-Dichloropicolinonitrile serves as a key intermediate in synthesizing kinase inhibitors. It functions as a crucial building block for JAK and BTK inhibitors through nucleophilic substitution and cyclization reactions, enabling construction of complex heterocyclic scaffolds in pharmaceutical development.
Synonyms: 3,5-Dichloro-2-cyanopyridine; 2-PYRIDINECARBONITRILE, 3,5-DICHLORO-;2-CYANO-3,5-DICHLOROPYRIDINE;3,5-DICHLORO-2-CYANOPYRIDINE;3,5-Dichloropicolinitrile;3,5-Dichloropyridine-2-carbonitrile;Cyanodichloropyridine 235---;3,5-Dichloro-2-pyridinecarbonitrile
EINECS: 674-558-4
Product Categories: Building Blocks;C6;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine series;Chemical Synthesis;Heterocyclic Building Blocks;Pyridines;Pyridine;Pyridines derivates
Mol File: 85331-33-5.mol
Physicochemical Properties
Melting point: 101-103°C
Boiling point: 271.9±35.0 °C
Storage temp: Sealed in dry,Room Temperature
Form: Powder to crystal
Color: White to light yellow