2-((5-bromopyrimidin-2-yl)oxy)ethan-1-ol
2-((5-bromopyrimidin-2-yl)oxy)ethan-1-ol•Pharmaceutical Intermediate
CAS: 1246922-88-2
MF: C6H7BrN2O2
MW: 219.04
Structural Formula
Usage
Used in the synthesis of macitentan, which is an endothelin receptor antagonist.
Specification
98%, 99%
Overview
2-((5-Bromopyrimidin-2-yl)oxy)ethan-1-ol serves as a key organic and pharmaceutical intermediate. It participates in nucleophilic substitution reactions to synthesize Macitentan, an endothelin receptor antagonist for treating pulmonary arterial hypertension.
Synonyms: 2-((5-bromopyrimidin-2-yl)oxy)ethan-1-ol; 2-(5-bromopyrimidin-2-yloxy)ethanol; 2-[(5-Bromo-2-pyrimidinyl)oxy]ethanol; Ethanol, 2-[(5-bromo-2-pyrimidinyl)oxy]-; Macitentan Impurity 41; Macitentan Impurity J
Mol File: 1246922-88-2.mol