5-(4-Bromophenyl)-4,6-dichloropyrimidine
A key intermediate and has a wide range of applications in the pharmaceutical and chemical fields.
Overview
5-(4-Bromophenyl)-4,6-dichloropyrimidine serves as a key organic intermediate for pharmaceuticals. It functions as a reactant in Macitentan synthesis, participating in coupling reactions to produce this oral dual endothelin receptor antagonist for treating pulmonary arterial hypertension.
Synonyms: PyriMidine, 5-(4-broMophenyl)-4,6-dichloro-; 5-(4-broMophenyl)-4,6-dichloropyriMidine; 5-(4-Bromophenyl)-4,6-dichloro-Pyrimidin; 5-(4-broMophenyl)-4; Macitentan Intermediate 1; 5-(4-Bromophenyl)-4,6-dichloropyrimidine(146533-41-7); Macitentan Impurity 26; potassiuM (N-propylsulfaMoyl)aMide
Product Categories: Pharmaceutical intermediates; Mazopitant intermediates; Pyrimidine; Pyrimidine derivatives; Other raw materials
Mol File: 146533-41-7.mol
Physicochemical Properties
Melting point: 98.0 to 102.0°C
Boiling point: 368.7±42.0°C(Predicted)
Storage temp: under inert gas (nitrogen or Argon) at 2-8°C
Solubility: Chloroform (Slightly), DMSO (Slightly)
Form: Solid
Color: Off-White
Stability: Light Sensitive