2-fluoro-4-phenoxyphenylboronic acid

2-Fluoro-4-phenoxyphenylboronic acid serves as a key synthetic intermediate in the preparation of rilzabrutinib, a Bruton's tyrosine kinase (BTK) inhibitor for treating autoimmune diseases. This boronic acid derivative undergoes Suzuki-Miyaura cross-coupling reactions to construct the essential biaryl ether scaffold of the drug molecule. The strategic incorporation of fluorine atoms enhances metabolic stability and binding affinity, enabling precise development of targeted therapeutics through efficient carbon-carbon bond formation in pharmaceutical synthesis.

Synonyms: (2-fluoro-4-phenoxyphenyl)boronic acid;Boronic acid, B-(2-fluoro-4-phenoxyphenyl)-;B-(2-Fluoro-4-phenoxyphenyl)boronic acid;(2-fluoro-4-phenoxyphenyl)boronic

Mol File: 1414356-30-1.mol