tert-butyl (R)-3-hydroxypiperidine-1-carboxylate
Used for organic synthesis and pharmaceutical intermediates; used to prepare piperidinyl butyrates and constrained SAH analogs as DNA methyltransferase inhibitors.
Overview
tert-Butyl (R)-3-hydroxypiperidine-1-carboxylate serves as a crucial chiral intermediate in pharmaceutical synthesis. This Boc-protected hydroxypiperidine enables the construction of constrained (-)-S-adenosyl-L-homocysteine analogs through selective deprotection and functionalization reactions. Its stereospecific structure is particularly valuable for developing advanced DNA methyltransferase inhibitors and various piperidinyl butyrate derivatives, where the hydroxyl group facilitates precise molecular modifications while maintaining optimal three-dimensional configuration for enhanced biological activity and target specificity in therapeutic applications.
Synonyms: (R)-1-Boc-3-Hydroxypiperidine; (R)-1-Boc-3-hydroxypiperidine 95%;tert-Butyl (3R)-3-hydroxypiperidine-1-carboxylate, (3R)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine;(R)-1-Boc-3-hydroxypiperidine,97%;(R)-1-N-BOC-3-HYDROXYPIPERIDINE;(R)-1-BOC-3-PIPERIDINOL;(R)-1-BOC-3-HYDROXYPIPERIDINE;R-3-HYDROXY-1-(TERT-BUTOXYCARBONYL)PIPERIDINE
Product Categories: Ibrutinib intermediate;Piperazine;Piperidine;Piperidines
Mol File: 143900-43-0.mol
Physicochemical Properties
Melting point:43-50°C
Boiling point: 292.3±33.0°C
Storage temp: 2-8°C
Solubility: Soluble in Methanol
Form: Low Melting Solid
Color: White