1H-pyrazolo[3,4-d]pyrimidin-4-amine

1H-Pyrazolo[3,4-d]pyrimidin-4-amine serves as a versatile heterocyclic intermediate with significant pharmacological applications. This adenine isomer functions as a potent inhibitor of Stx1-catalyzed enzymatic reactions and demonstrates substantial mTOR inhibitory activity. As a well-characterized tyrosine kinase inhibitor scaffold, it effectively blocks Src kinase by targeting adenosine binding sites through strategic molecular interactions. The compound's remarkable ability to significantly reduce serum cholesterol levels in preclinical models further highlights its therapeutic potential. Its multifaceted bioactivity makes it particularly valuable for developing targeted therapies across infectious diseases, oncology, and metabolic disorders through rational molecular design and optimization.

Synonyms: 4-Aminopyrazolo[3,4-d]pyrimidine; TIMTEC-BB SBB004205;1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE; 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE;4-AMINO-1H-PYRAZOLO[3,4-D]PYRIMIDINE;ADENINE ANTIMETABOLITE;4- aMinopyrazolo [3,4-d] pyriMidines;PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE

EINECS: 219-174-6

Product Categories: Heterocyclic Compounds;Heterocycles;PYRIMIDINE;Pyridines, Pyrimidines, Purines and Pteredines;Heterocycle-Pyrimidine series

Mol File: 2380-63-4.mol