2-amino-4-chlorophenol
Used as a pharmaceutical intermediate; used in the synthesis of various drugs, dyes, pesticides, and aggrecanase-2 inhibitors for osteoarthritis treatment.
Overview
2-Amino-4-chlorophenol serves as a key chemical intermediate in pharmaceutical synthesis and industrial applications. This versatile compound functions as a crucial building block for developing aggrecanase-2 inhibitors featuring acylthiosemicarbazide zinc-binding groups, representing promising therapeutics for osteoarthritis treatment. Through condensation and complexation reactions, it enables precise construction of zinc-chelating pharmacophores that effectively target cartilage-degrading enzymes. Beyond pharmaceuticals, this chlorinated aminophenol derivative finds extensive use in dye manufacturing and pesticide synthesis, demonstrating remarkable functional versatility across multiple chemical domains.
Synonyms: 2-amino-4-chloro-pheno;2-Hydroxy-5-chloroaniline;2-AMINO-4-CHLOROPHENOL FOR SYNTHESIS;2-AMino-4-chlorophenol, 97% 100GR;C.I. 76525;C.I. Oxidation Base 18;c.i.76525;c.i.oxidationbase18
EINECS: 202-458-9
Product Categories: Dyestuff Intermediates;Building Blocks;C6 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Anilines, Aromatic Amines and Nitro Compounds;Phenoles and thiophenoles;Dye Intermediate;Phenols
Mol File: 95-85-2.mol
Physicochemical Properties
Melting point: 136-141°C
Boiling point: 185.5°C
Storage temp: 2-8°C
Solubility: 2.3g/l
Water Solubility: Insoluble. <0.1 g/100 mL at 20 ºC
Form: Solid
Color: Pale Orange to Light Brown
Stability: Stable. Incompatible with strong oxidizing agents.