N-(2-Bromoethyl)phthalimide
Used for organic synthesis and pharmaceutical intermediates; used to prepare 2-(2-bromo-ethyl)-3-hydroxy-3-phenyl-isoindolin-1-one via reaction with phenyl magnesium bromide.
Overview
N-(2-Bromoethyl)phthalimide serves as a key synthetic intermediate for ensifentrine and other pharmaceutical compounds. This versatile building block undergoes nucleophilic substitution and Gabriel amine synthesis reactions to construct essential ethylenediamine derivatives, enabling precise development of PDE3/PDE4 dual inhibitors for respiratory disease treatment through controlled functional group transformations.
Synonyms: AURORA KA-575;BETA-BROMOETHYLPHTHALIMIDE;2-(2-BROMO-ETHYL)-ISOINDOLE-1,3-DIONE;TIMTEC-BB SBB003129;1-Bromo-2-phthalimidoethane;1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-;2-(2-Bromoethyl)-1H-isoindole-1,3(2H)-dione;2-(2-bromoethyl)-1h-isoindole-3(2h)-dione
EINECS: 209-379-9
Product Categories: N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Phthalimides;Bifunctional CrosslinkersOrganic Building Blocks;Carbonyl Compounds;Cyclic Imides;Linkers;Peptide Synthesis;Bifunctional Linkers;Building Blocks;Carbonyl Compounds;Chemical Biology;Chemical Synthesis;Cyclic Imides;Linkers and Crosslinkers;Organic Building Blocks;alkyl bromide
Mol File: 574-98-1.mol
Physicochemical Properties
Melting point: 80-83°C
Boiling point: 318°C
Storage temp: Sealed in dry,Room Temperature
Water Solubility: insoluble
Form: Crystalline powder
Color: White to slightly pink or beige