9,10-dimethoxy-2-(2,4,6-trimethylanilino)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one

9,10-Dimethoxy-2-(2,4,6-trimethylanilino)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one serves as a key intermediate in synthesizing ensifentrine, a dual PDE3/PDE4 inhibitor for COPD treatment. This complex heterocyclic compound undergoes selective functionalization and cyclization reactions to construct the essential tricyclic core structure, enabling precise development of bronchodilators with combined pharmacological activities.

Synonyms: 9,10-dimethoxy-2-(2,4,6-trimethylanilino)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one;6,7-Dihydro-9,10-dimethoxy-2-[(2,4,6-trimethylphenyl)amino]-4H-pyrimido[6,1-a]isoquinolin-4-one;4H-Pyrimido[6,1-a]isoquinolin-4-one, 6,7-dihydro-9,10-dimethoxy-2-[(2,4,6-trimethylphenyl)amino]-;2-(Mesitylamino)-9,10-dimethoxy-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one;9,10-dimethoxy-2-(2,4,6-trimethylanilino)-6,7-dihydro-4H-pyrimido(6,1-a)isoquinolin-4-one;Ensifen Group Impurities 28

Mol File: 76536-66-8.mol