(R)-2-AMINO-1,1,1-TRIFLUOROPROPANE HYDROCHLORIDE

(R)-2-Amino-1,1,1-trifluoropropane hydrochloride serves as a key chiral intermediate in synthesizing vorasidenib, an IDH1/2 inhibitor for glioma treatment. This trifluoromethyl-containing building block undergoes nucleophilic substitution and amidation reactions to construct the essential chiral side chain of the drug molecule. Its unique stereochemistry and fluorine atoms significantly enhance the metabolic stability and target binding affinity of the final therapeutic agent.

Synonyms: (R)-1,1,1-trifluoropropan-2-amine HCl;(2R)-1,1,1-tris(fluoranyl)propan-2-amine hydrochloride;R-TFIPMHCL;(R)-2-AMINO-1,1,1-TRIFLUOROPROPANE HYDROCHLORIDE;(R)-1,1,1-TRIFLUOROISOPROPYLAMINE HYDROCHLORIDE;(2R)-1,1,1-trifluoropropan-2-aMine hydrochloride;(R)-1,1,1-Trifluoropropan-2-aMine hydrochloride;(R)-2-AMINO-1,1,1-TRIFLUOROPROPANE HCL

Mol File:177469-12-4.mol