6-CHLORO-2-PICOLINIC ACID METHYL ESTER
Used for organic synthesis and pharmaceutical intermediates; used to prepare methyl 2,2'-bipyridine-6-carboxylate via coupling reactions.
Overview
6-Chloro-2-picolinic acid methyl ester serves as a key intermediate in synthesizing vorasidenib, an IDH1/2 inhibitor for glioma treatment. This chlorinated picolinate undergoes Stille cross-coupling reactions with stannylpyridine derivatives to construct the essential bipyridine core structure, enabling precise development of targeted cancer therapeutics through efficient carbon-carbon bond formation.
Synonyms: Methyl 6-Chloropyridine-2-carboxylate, 97+%;METHYL 6-CHLOROPYRIDINE-2-CARBOXYLATE;AKOS BBS-00004651;6-CHLOROPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER;6-CHLORO-2-PICOLINIC ACID METHYL ESTER;6-Chloro-2-pyridinecarboxylic acid methyl ester;6-Chloropicolinic acid methyl ester;2-Pyridinecarboxylic acid, 6-chloro-, methyl ester
EINECS: 808-173-1
Product Categories: Picolinic acid series
Mol File: 6636-55-1.mol
Physicochemical Properties
Melting point: 93-94°C
Boiling point:275.8±20.0°C
Storage temp: Keep in dark place,Sealed in dry,Room Temperature
Water Solubility: Slightly soluble in water.
Form: Solid
Color: Pale yellow