4-Amino-2,6-dichlorophenol
Used as a pharmaceutical intermediate.
Overview
4-Amino-2,6-dichlorophenol serves as a key intermediate in synthesizing Resmetirom, a thyroid hormone receptor beta agonist for treating NASH. This dichlorinated aminophenol undergoes selective etherification and sequential amidation reactions to construct the core phenoxy structure of the drug molecule, enabling precise development of targeted metabolic disease therapeutics.
Synonyms: 3,5-Dichloro-4-hydroxyaniline;4-amino-2,6-dichloro-pheno;4-Amino-2,6-Dichlorophenol 2,6-Dichloro-4-Aminophenol;2,6-dichloro-4-chloro phenol;2,6-dichloro-4-amine phenol;4-Amino-2,6-dichlorophenol, 97+%;4-AMINO-2,6-DICHLOROPHENOL / 3,5-DICHLORO-4-HYDROXYANILINE;4-amino-2,6-dichlorophen-3,5-D2-ol
EINECS: 227-671-4
Product Categories:Organic Building Blocks;Oxygen Compounds;Aromatic Phenols;Phenoles and thiophenoles;Phenols;Dyestuff Intermediates
Mol File: 5930-28-9.mol
Physicochemical Properties
Melting point: 167-170°C
Boiling point: 303.6±42.0°C
Storage temp: Keep in dark place,Inert atmosphere,Room temperature
Solubility:Soluble in methanol
Form: Powder
Color: Beige or slightly brown to pale reddish
Stability: Stable. Incompatible with acids, acid chlorides, acid anhydrides, chloroformates, strong oxidizing agents.