1-Methylpyrrolidine
Used as a pharmaceutical intermediate; used as a fundamental building block in the structure of Cefepime and studied as a component in cigarette smoke.
Overview
1-Methylpyrrolidine serves as a key structural component in the synthesis of cefepime hydrochloride, a fourth-generation cephalosporin antibiotic. This methylated pyrrolidine is incorporated into the cephalosporin core through quaternization reactions, forming the essential pyrrolidinium moiety that enhances the drug's antibacterial activity and stability against β-lactamases. Its structural integration is critical for developing advanced antibiotics with improved pharmacological properties.
Synonyms: 1-METHYLPYRROLIDINE;1-methyl;1-methyl-pyrrolidin;1-METHYLPYRROLIDINE FOR SYNTHESIS;cefepiMe iMpurity G;N-Methylpyrrolidine;1-Methylpyrrolidine >=98.0% (GC);N-Methylpyrrolidine 97%
EINECS: 204-438-5
Product Categories:Chemical Synthesis;Heterocyclic Building Blocks;Aliphatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Building Blocks;Heterocyclic Building Blocks;Pyrrolidines;Building Blocks;C4 to C8
Mol File: 120-94-5.mol
Physicochemical Properties
Melting point: -90°C
Boiling point: 76-80°C
Storage temp: Store below +30°C.
Solubility:213g/l
Form: Liquid
Color: Clear colorless