Hydroxymethyl-7-Aminocephalosporanic acid
Used as a pharmaceutical intermediate; used in the synthesis of semi-synthetic cephalosporins.
Overview
Hydroxymethyl-7-Aminocephalosporanic acid serves as a key intermediate in the semi-synthetic production of advanced cephalosporin antibiotics. This critical β-lactam building block, naturally occurring in Acremonium chrysogenum, enables the synthesis of fourth-generation cephalosporins including cefepime hydrochloride through strategic acylation reactions at the 7-amino position and side chain modifications at the 3-hydroxymethyl group. Its versatile chemical functionality allows for the introduction of various side chains that enhance antibacterial spectrum and pharmacokinetic properties, making it particularly valuable for developing broad-spectrum antibiotics with improved stability against β-lactamases.
Synonyms: 7-ACA Impurity 1（Deacetyl 7-ACA）;7-HACA;Ceftriaxone Impurity 22;Cephalosporin impurity 1;7-ACA Impurity D;Cefazedone Impurity 11;(2S)-N-[(2S,4R)-4-acetamido-1-[[(2S)-2-[[(2R)-6-amino-2-[[(2S)-3-(4-hydroxyphenyl)-2-(methylamino)-1-oxopropyl]amino]-1-oxohexyl]amino]-4-methyl-1-oxopentyl]-[(2S)-2-[[(2R)-2-amino-1-oxo-3-(3-pyridiny;7-Amino-3-(hydroxymethyl)-cephem-4-carboxylic acid
EINECS: 239-787-2
Product Categories:Cefcapene
Mol File: 15690-38-7.mol
Physicochemical Properties
Melting point: 105-107°C
Boiling point: 617.9±55.0°C
Storage temp: Keep in dark place,Inert atmosphere,Room temperature
Solubility: Chloroform (Slightly), Methanol (Slightly)
Form: Solid
Color: White to Beige